Table 1.
Correlation of Zonula Occludens-1 (ZO-1) expression in tumor tissues with clinicopathologic characteristics in non-small cell lung cancer (NSCLC) patients
| NSCLC | n | Low or no expression | High expression | Pearson χ2 | P |
|---|---|---|---|---|---|
|
| |||||
| Total | 104 | 35 | 69 | ||
| Gender | 0.633 | 0.426 | |||
| male | 72 | 26 (36.11) | 46 (63.89) | ||
| female | 32 | 9 (28.13) | 23 (71.88) | ||
| Age at diagnosis (years) | 4.151 | 0.042* | |||
| ≤60 | 41 | 9 (21.95) | 32 (78.05) | ||
| >60 | 63 | 26 (41.27) | 37 (58.73) | ||
| Tumor diameter (cm) | 0.610 | 0.435 | |||
| ≤3 | 35 | 10 (28.57) | 25 (71.43) | ||
| >3 | 69 | 25 (36.23) | 44 (63.77) | ||
| Histological type | 0.003 | 0.957 | |||
| squamous cell carcinoma | 47 | 16 (34.04) | 31 (65.96) | ||
| adenocarcinoma | 55 | 19 (34.55) | 36 (65.45) | ||
| others | 2 | 0 | 2 | ||
| Differentiation | 0.926 | 0.629 | |||
| Well | 8 | 3 (37.50) | 5 (62.50) | ||
| Moderate | 66 | 24 (36.36) | 42 (63.64) | ||
| Poorly | 30 | 8 (26.67) | 22 (73.33) | ||
| Lymph node metastasis | 0.976 | 0.614 | |||
| No regional lymph node metastasis | 53 | 16 (30.19) | 37 (69.81) | ||
| Metastasis in ipsilateral peribronchial | 27 | 9 (33.33) | 18 (66.67) | ||
| Metastasis in mediastinal | 24 | 10 (41.67) | 14 (58.33) | ||
| Stage Grouping with TNM | 1.641 | 0.440 | |||
| Stage I | 50 | 14 (28.00) | 36 (72.00) | ||
| Stage II | 28 | 10 (35.71) | 18 (64.29) | ||
| Stage III | 26 | 11 (33.65) | 15 (66.35) | ||
*
P<0.05.