Table 2.
Comparisons of ionotropic glutamate receptor immunoreactivity in brain regions following limited and binge cocaine self-administration and withdrawal
| VTA
|
SN
|
NAc
|
Striatum
|
PFC
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ANOVA | Post hoc | ANOVA | Post hoc | ANOVA | Post hoc | ANOVA | Post hoc | ANOVA | Post hoc | |
| NR1 | 0.002 | B > C,W | < 0.001 | W,B > C | ||||||
| NR2B | < 0.001 | W,B > C | < 0.001 | W > C,B | ||||||
| NR3A | < 0.001 | B > C,W | 0.011 | C,B > W | ||||||
| NR3B | < 0.001 | B > W > C | ||||||||
| GluR1 | 0.014 | W > B | 0.002 | B > C,W | < 0.001 | W > C,B | 0.027 | |||
| GluR2/3 | 0.028 | W > B | 0.016 | W > B | < 0.001 | W > C > B | 0.006 | W > C,B | ||
| GluR4 | < 0.001 | W > C,B | 0.003 | W > C,B | ||||||
| GluR5 | 0.027 | C > B | 0.041 | B > W | 0.002 | W > C,B | ||||
| GluR6/7 | < 0.001 | C,W > B | 0.031 | B > W | < 0.001 | W > C,B | ||||
| KA2 | < 0.001 | B > C,W | < 0.001 | W > C,B | ||||||
C, control; B, binge; W, withdrawal. Post-hoc comparisons revealed statistically significant differences at p < 0.05.