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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Clin Cancer Res. 2013 Sep 17;19(22):10.1158/1078-0432.CCR-13-0145. doi: 10.1158/1078-0432.CCR-13-0145

Figure 2.

Figure 2

MAPK signaling pathway is upregulated in OSI-906 resistant CRC lines. Gene set enrichment analysis revealed that MAPK signaling pathway is upregulated in OSI-906 resistant lines, suggesting a rational combination of OSI-906 with a MEK inhibitor (MEKi) might reveal synergistic effects in OSI-906 resistant cell lines. Green and red ovals represent genes upregulated in OSI-906 sensitive and resistant lines, respectively. This pathway is modified from the KEGG insulin signaling pathway previously identified as one of the top enriched pathways in OSI-906 resistant CRC lines (15).