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Effect of OSI-906 and U0126 alone and in combination on downstream effectors. (A) Five CRC cell lines were exposed to OSI-906 and U0126 for 6 h. (B) Five CRC cell lines were exposed to OSI-906 and U0126 for 24 h. S and R represent sensitivity or resistance to OSI-906. Cell lines are listed in order from most sensitive to most resistant to U0126.
