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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Chem Biol. 2013 Sep 19;20(9):10.1016/j.chembiol.2013.09.002. doi: 10.1016/j.chembiol.2013.09.002

Figure 1.

Figure 1

Screening and preclinical path for hits dissipating the membrane’s electrical potential (Δψ) or proton gradient (ΔpH). The inset simplifies the membrane and respiratory chain as drug target sites; not shown is the peptidoglycan and unknown membrane-embedded proteins that could interact with membrane-active agents. The DiSC3(5) florescence data in the graph was derived from Farha et al., (2013).