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. 2013 Nov 16;3:24. doi: 10.1186/2045-9912-3-24

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Copyright © 2013 Ekundi-Valentim et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of treatment with single oral doses of naproxen or ATB-346 on leukocyte recruitment to the knee joint cavity secondary to CGN-induced synovitis in rats. CGN-injected animals were orally pre-treated with naproxen (at 0.3, 1, 3 and 10 mg/kg; n = 8), equimolar ATB-346 doses (0.48, 1.6, 4.8 and 16 mg/kg; n = 8) or vehicle (1 ml/kg; n = 8). A separate control group (Sham - S) received only an i.art. injection of saline injection (n = 5). The bars represent the mean ± SEM values of the number of total leukocytes (panel A), neutrophils (panel B), monocytes (panel C) or lymphocytes (panel D) per cavity measured 5 h after CGN injection. ***P < 0.001 vs. S; ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001 vs. vehicle-treated (V) group, as analysed by one-way ANOVA followed by the Bonferroni's multiple comparison test.