Figure 3.

DNA methylation and serum levels of IGFBP1 according to body mass index. (A) No differences were found in the IGFBP1 DNA methylation levels between lean and overweight/obese subjects in non-diabetic control subjects, newly diagnosed and treated type 2 diabetes patients. (B) However, lean individuals had significantly higher serum IGFBP-1, lower insulin and similar glucose levels compared with subjects who were overweight/obese. BMI, body mass index; IGFBP-1, insulin-like growth factor binding protein-1; NGT, normal glucose tolerance; T2D, type 2 diabetes.