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Multivariate relative risks of an application for an orphan designation at EMA or FDA
| Variable | Univariate RR (95% CI) | Multivariate RR (95% CI) |
|---|---|---|
|
Prevalence |
|
|
| 1-9/1.000.000 |
5.0 (2.7–9.2) |
2.8 (1.4–5.4) |
| <1/1.000.000 |
Ref |
Ref |
|
Preclinical proof of concept? |
|
|
| Yes |
6.0 (3.0–12.0) |
3.9 (1.9–8.3) |
| No | Ref | Ref |
