Table 1. Number and mean plaque size in mock- or Tat-virus-injected APP/PS1 mouse hippocampi.
Virus | Mixed Tat | Syn-Tat | ||
Control | Tat | Control | Tat | |
Number of sections | 5 | 5 | 7 | 7 |
Number of plaques | 45 | 86 | 68 | 86 |
Plaque number/brain slice | 9 | 17.5 | 9.71 | 12.28 |
Mean Plaque size (µM) | 24.919±4.46 | 36.151±3.37 | 40.587±8.92 | 45±5.64 |
% Increase | 145.0734 | 110.893 |
Lentiviruses containing an expression construct for mock or Tat were injected stereotaxically into the hippocampus of APP/PS1 mice. After 4 months, sections of brain were stained with Aβ antibody and the number and size of plaques were determined using Axiovision software (Carl Zeiss). Results represent the mean ± s.d.