Table 3. Meta-analysis of miR-499 and miR-149 with gastrointestinal cancer susceptibility.
| MiR-499 | GG vs AA | AG vs AA | G vs A | GG+AG vs AA | GGvs AG+AA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | |
| Total | 11 | 1.33(0.96,1.85) | 0.03 | 1.02(0.85,1.21) | 0.006 | 1.13(0.96,1.33) | <0.0001 | 1.08(0.90,1.30) | 0.001 | 1.34(0.99,1.80) | 0.04 |
| Cancer type | |||||||||||
| HCC | 4 | 1.27(0.60,2.69) | 0.04 | 0.99(0.78,1.26) | 0.16 | 1.12(0.77,1.62) | 0.004 | 1.09(0.73,1.64) | 0.02 | 1.26(0.92,1.73) | 0.11 |
| GC | 2 | 1.28(0.85,1.93) | 0.42 | 0.92(0.76,1.11) | 0.48 | 1.01(0.87,1.18) | 0.22 | 0.96(0.80,1.15) | 0.31 | 1.31(0.87,1.96) | 0.47 |
| CRC | 2 | 1.66(1.02,2.70) | 0.12 | 0.94(0.74,1.20) | 0.10 | 1.14(0.94,1.37) | 0.16 | 1.05(0.83,1.31) | 0.96 | 1.64(0.61,4.43) | 0.05 |
| Others | 3 | 1.39(0.51,3.78) | 0.02 | 1.21(0.74,1.97) | 0.007 | 1.25(0.75,2.00) | 0.0001 | 1.23(0.72,2.11) | 0.0005 | 1.33(0.55,3.21) | 0.04 |
| Ethnicity | |||||||||||
| Caucasian | 2 | 1.59(0.79,3.16) | 0.09 | 0.80(0.56,1.14) | 0.26 | 1.20(0.97,1.48) | 0.29 | 1.05(0.76,1.43) | 0.95 | 1.69(0.76,3.78) | 0.03 |
| Asian | 9 | 1.26(0.84,1.89) | 0.03 | 1.06(0.87,1.28) | 0.006 | 1.11(0.91,1.35) | <0.0001 | 1.09(0.88,1.35) | 0.0003 | 1.27(0.99,1.63) | 0.10 |
| MiR-149 | TT vs CC | TC vs CC | T vs C | TT+TC vs CC | TT vs TC+CC | ||||||
| N | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | OR (95%CI) | Ph | |
| Total | 7 | 1.02(0.84,1.24) | 0.79 | 0.83(0.69,1.00) | 0.99 | 1.06(0.97,1.16) | 0.81 | 0.92(0.77,1.10) | 0.98 | 1.15(1.03,1.30) | 0.68 |
| Cancer type | |||||||||||
| CRC | 3 | 1.07(0.81,1.42) | 0.62 | 0.86(0.66,1.11) | 1.00 | 1.06(0.94,1.21) | 0.98 | 0.94(0.74,1.20) | 0.99 | 1.16(0.97,1.38) | 0.63 |
| GC | 2 | 0.99(0.70,1.40) | 0.98 | 0.79(0.56,1.12) | 0.63 | 1.07(0.92,1.25) | 0.88 | 0.89(0.64,1.24) | 0.79 | 1.18(0.96,1.45) | 0.61 |
| Others | 2 | 0.95(0.62,1.46) | 0.17 | 0.82(0.52,1.30) | 0.54 | 1.07(0.76,1.51) | 0.09 | 0.90(0.59,1.36) | 0.31 | 1.11(0.87,1.42) | 0.10 |
| Ethnicity | |||||||||||
| Asian | 6 | 0.99(0.81,1.21) | 0.85 | 0.83(0.67,1.02) | 0.98 | 1.06(0.97,1.16) | 0.71 | 0.91(0.75,1.11) | 0.95 | 1.14(1.01,1.29) | 0.69 |
P h: P value of Q-test for heterogeneity test.Random-effects model was used when a P value<0.10 for heterogeneity test; otherwise, fixed-effects model was used.