Table 2. Quantitation of microvessels in human biopsies of colorectal carcinoma.
|
|
3-D analysis Spatial microvessel density (microvessel volume/tissue volume) × 100% | 2-D analysis Microvessel countsa (microvessel number/per field area of 0.21 mm2) | |
|---|---|---|---|
| Tumor (Regions in Figure 5) | C | 12.1 | 14.0 |
| D | 14.6 | 30.3 | |
| E | 10.6 | 29.0 | |
| F | 13.3 | 62.3 | |
| G | 11.9 | 53.3 | |
| Average (C-G) | 12.6 ± 1.5 (mean ± SD)b | 38.2 ± 20.0 (mean ± SD)b,c | |
| Adjacent to tumor (control) | H | 3.8 | 21.3 |
| I | 2.5 | 20.0 | |
| Average (H & I) | 3.2 | 20.7 | |
a Counts were evaluated by 3 independent examiners. b SD: standard deviation. c The analysis was taken at 30 μm under the tissue surface. The (mean ± SD) values at 15 and 60 μm under the tissue surface are (30.0 ± 16.1) and (26.0 ± 6.6), respectively.