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. 2013 Nov 29;8(11):e82140. doi: 10.1371/journal.pone.0082140

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© 2013 Skeie, Mahajan

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A. Retinal STAT1 hub showing proteins associated with STAT1 pathways in the eye through specific interactions. STAT1 is a transcription activator associated with disease. B. Calpain-1 hub expanding pathways associated with calpain-1 in the mouse vitreous. Calpain-1 is an intracellular cysteine protease. C. Superoxide dismutase 1 (SOD1) and associated proteins were also found in the mouse vitreous. SOD1 is elevated in the vitreous of diabetic patients. Edges denote interactions (binding, substrate, transcriptional target) and are color-coded (green = activation; red = inhibition; black = unknown).