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. 2013 Nov;3(11):130100. doi: 10.1098/rsob.130100

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© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — The structures of the HIV-1 Vif SOCS peptide and the SOCS–EloBC complex. (a) SOCS peptide alignment. Overlap of ten backbone structures for the SOCS-box after Rosetta refinement. (b) Structural comparison with the SOCS-box crystal structure (3DCG, chain E). Peptide structure is aligned against the crystal structure in green. The 165PLS167 sequence is highlighted in yellow. (c) 20 structures of the SOCS–EloBC complex with the lowest energy are aligned after HADDOCK refinement. (d) Ribbon representation of the complex. The Vif SOCS peptide is coloured in red. EloB and EloC are in blue and grey, respectively. The 165PLS167 region of SOCS is highlighted in yellow.