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AROS is redundant for survival in non-cancer cell lines. (a) Phase contrast micrographs 72 h following targeting of AROS or SIRT1 in ARPE19, WI-38 and MCF10A non-cancer cells. (b) Western blotting for AROS protein following RNAi in each cell line. β-Actin is used as a loading control. (c) Quantification of apoptotic induction following targeting of SIRT1 and AROS in non-cancer cells. Apoptosis following mock transfection is set to 1.0.
