Figure 2.

Relative size and distribution of mitochondria and spines in neuronal dendrites. Dendrites of cultured hippocampal neurons days in vitro (DIV) are shown with mitochondria labelled with mitochondria-targeted red fluorescence protein (RFP; red) (a), and in merge with dendritic spines labelled with yellow fluorescence protein (YFP)-actin (green) (b). Dendritic mitochondria range in length from 1–2 µm to 20–30 µm. In most cases, a single mitochondrion spans a distance that encompasses multiple dendritic spines.