Figure 3.

UV uncaging of a calcium buffer after LTP induction prevents stabilization of LTP: (a) mean data for EPSC amplitude versus time for whole-cell patch-clamp experiments from CA1 pyramidal neurons with diazo-2 included in the intracellular solution (open circles); UV light applied at the time point is indicated by the arrow. For controls (filled circles), either UV light was applied to neurons with no diazo-2 in the intracellular solution (n = 6), or neurons contained diazo-2 and no UV light was applied (n = 2). Bar and asterisk (*) indicate significant difference (p < 0.05) between diazo-2 and control datasets at the time indicated. (b) Example averaged EPSC traces from a diazo-2 and a control experiment taken at the times indicted in (a).