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Schematic for the mechanism of LTP expression at silent synapses: during baseline, silent synapses lack surface-expressed AMPA receptors but contain NMDA receptors. Immediately after LTP induction (less than 15 min), GluA2-lacking AMPA receptors are selectively incorporated at silent synapses. Calcium influx through GluA2-lacking AMPA receptors drives their subsequent replacement by GluA2-containing receptors (more than 15 min) during LTP consolidation.
