Table II.

Differential Increase (A) and Decrease (B) in miRNA Expression in Livers of C57BL/6 and Keap1-KD mice After CR

Identity	Fold Change
A
mmu-miR-193	3.36
mmu-miR-149	3.20
mmu-miR-434-5p	3.73
mmu-miR-34b-5p	8.33
mmu-miR-205	10.61
mmu-miR-455	3.60
mmu-miR-343	3.20
mmu-miR-692	102.54
B
mmu-miR-184	−4.63
mmu-miR-135a	−4.18
mmu-miR-146b	−14.55
mmu-miR-802	−6.07
mmu-miR-665	−4.32
mmu-miR-383	−4.24
mmu-miR-200b*	−4.21
mmu-miR-449b	−4.57
mmu-miR-667	−4.63
mmu-miR-150*	−5.11
mmu-miR-411*	−5.91
mmu-miR-466j	−6.42
mmu-miR-485*	−11.26
mmu-miR-92a*	−6.69
mmu-miR-1898	−5.06
mmu-miR-1899	−4.06

RNA fraction enriched for small RNAs was isolated from livers of C57BL/6 and Keap1-KD mice that were placed on caloric restriction and miRNA expression was quantified from pooled RNA samples by RT² -PCR using a Mouse Genome V2.0 miRNA array from SABiosciences as per manufacturer’s instructions. Data analysis was performed with the web-based software package for the miRNA PCR array system. (http://www.sabiosciences.com/pcr/arrayanalysis.php). Data is presented as fold increase or decrease in miRNA expression of Keap-1KD CR relative to C57BL/6 CR