Table 1.

Hypothesized Relationship between QLQ-C30 and SCNS-SF34 Domains and Resulting Areas Under the Curve (AUC): Original and Replication Analysis

QLQ-C30 Domain		SCNS-SF34 Domain/Item(s)	AUC
			Original Analysis[14]	Replication Analysis
Hypothesized AUC≥0.70
Physical Function		Physical & Daily Living Needs (overall score and individual items)	0.69–0.81	0.69–0.74
Role Function		Work around the home Not being able to do the things you used to	0.71–0.73	0.70–0.70
Emotional Function		Psychological Needs (overall score and individual items)	0.56–0.74	0.61–0.75
Pain		Pain	0.78	0.74
Fatigue		Lack of energy/tiredness	0.74	0.75
Global Health/QOL		Feeling unwell a lot of the time	0.73	0.76
Hypothesized AUC <0.70
Social Function		Not being able to do the things you used to	0.64	0.68
Sleep		Lack of energy/tiredness Feeling unwell a lot of the time Being given information…about aspects of managing your illness and side-effects at home	0.41–0.51	0.39–0.55
Cognitive Function		Feeling unwell a lot of the time Being given information…about aspects of managing your illness and side-effects at home	0.54–0.60	0.53–0.63
Nausea/Vomiting			0.19–0.36	0.22–0.27
Dyspnea			0.37–0.48	0.32–0.48
Appetite Loss			0.47–0.49	0.32–0.49
Constipation			0.31–0.37	0.32–0.40
Diarrhea			0.34–0.34	0.18–0.21