. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Crit Rev Oncol Hematol. 2013 Aug 7;88(3):10.1016/j.critrevonc.2013.07.002. doi: 10.1016/j.critrevonc.2013.07.002

Table 1.

Change in bone mineral density in women with breast cancer undergoing treatment and receiving calcium and vitamin D supplementation alone or with placebo

Authors	N	Treatments	Time Frame	BMD Change from baseline
Premenopausal women
Kim et al.[56]	112	500 mg calcium, 1000 IU vit D	12 months	Lumbar spine: -7.5%; Femoral Neck: - 3.4%
Shapiro et al.[57]	439	1000 mg calcium, 400 IU vit D	12 months	Lumbar spine: ovarian failure:-6.7%
Hershman et al.[59]	85	1000 mg calcium, 400 IU vit D + placebo	12 months	Lumbar spine: -5.4%, femoral neck: - 1.5%, total hip: -1.9%
Hershman et al.[59]	57	1000 mg calcium, 400 IU vit D + placebo	24 months	Lumbar spine: -6.3%, femoral neck: - 2.4%, total hip: -2.6%
Hines et al.[60]	216	600 mg calcium, 400 IU vit D + placebo	12 months	Lumbar spine: -5.4%, femoral neck: - 2.4%, total hip: -3.4%
Hershman et al.[58]	103	1000 mg calcium, 400-800 IU vit D + placebo	12 months	Lumbar spine: -4.39%, femoral neck: - 1.5%, total hip: -2.08%
Fuleihan et al.[61]	40	500 mg calcium, 400 IU vit D + placebo	12 months	Lumbar spine: -3.2%, total hip: -2.8%; amenorrhic women lost 4% BMD at both lumbar spine & total hip

Postmenopausal women
Prieto-Alhambra et al.[62]	232	1000 mg calcium carbonate, 800 IU vit D + 16,000 IU D₃	12 months	Total hip: -0.72%, femoral neck: - 1.49%, lumbar spine: -1.68%
Sergi et al.[63]	51	1000 mg calcium carbonate, 800 IU vit D	24 months	Lumbar spine: -3%, trochanter: - 4.0%, femoral neck: -4.1%.
Safra et al.[64]	90	1200 mg calcium carbonate, 400 IU vit D	12 months	Lumbar spine: -5.89%,
Safra et al.[64]	90	1200 mg calcium carbonate, 400 IU vit D	24 months	Lumbar spine: -6.51%,
Rastelli et al.[65]	60	1000 mg calcium carbonate, 400 IU vit D + 50,000 IU vit D₂	6 months	Spine: -0.36%, femoral neck: -1.39%, total femur: +0.04%
Rastelli et al.[65]	60	1000 mg calcium carbonate, 400 IU vit D + 50,000 IU vit D₂	6 months	Vit D group: Spine: 0.12%, femoral neck: 0.45%, total femur: -0.005%
Markopoulus et al.[66]	213	1000 mg calcium, 400 IU vit D	12 months	T ≥ -1: Lateral spine -5.3%; Hip -2.4%
			12 months	-2<T<-1: Lateral spine 0%; hip%: - 1.3%
			24 months	T ≥ -1: Lateral spine -2.5%; Hip -5.7%
			24 months	-2<T<-1: Lateral spine -1.5%; hip: - 3.9%
Van Poznak et al.[67]	234	1000 mg elemental calcium, 400 IU vit D	12 months	A only: Lateral spine -0.6%; Hip: - 0.4%
			12 months	A+P: Lateral spine -1.2%; Hip: -0.4%
			24 months	A only: Lateral spine -2.1%; Hip: - 0.4%
			24 months	A+P: Lateral spine -1.8%; Hip: -1.1%
Ellis et al.[68]	252	1000 mg calcium, ≥ 400 IU vit D + placebo	24 months	Lumbar spine: -1.5%
Greenspan et al.[69]	87	500 mg calcium carbonate, 200 IU vit D for participants consuming < 1200 mg dietary calcium	24 months	Posterior Anterior Spine: -4.8%; Lateral spine: -5.2%; Total hip: -2.8%; Trochanter: -4.2%; Femoral neck: - 2.4%; Total radius: -3.0%
Lester et al.[70]	131	500 mg calcium, 400 IU vit D + placebo	12 months	Lumbar spine: -2.35%; total hip: - 2.27%
Lester et al.[70]	131	500 mg calcium, 400 IU vit D + placebo	24 months	Lumbar spine: -3.22%; total hip: - 3.90%
Sawka et al.[71]	70	800-1000 IU vit D, 1500 mg elemental calcium (diet+supplements)	12 months	Lumbar spine: -1.4%
Sawka et al.[71]	70		12 months	Femoral Neck: -1.7%

A = Anastrozole; A+P = Anastrozole+ Placebo