Table 1.
Demographic and laboratory characteristics of participants, based on APOL1 risk status
| Variable | 0 or 1 APOL1 risk alleles (N=170) | 2 APOL1 risk alleles (N=130) | P-value4 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean | Std | Median | N | Mean | Std | Median | ||
| African ancestry (%) | 161 | 0.81 | 0.10 | 0.83 | 127 | 0.82 | 0.09 | 0.83 | 0.4411 |
| Age (years) | 170 | 54.69 | 11.71 | 55.00 | 130 | 47.14 | 12.96 | 49.00 | <.0001 |
| Age difference (years)2 | 167 | 6.78 | 9.11 | 9.00 | 128 | 3.84 | 7.05 | 4.00 | 0.0017 |
| Female (%) | 98 | 57.7% | 80 | 61.5% | 0.4965 | ||||
| BMI (kg/m2)\ | 166 | 34.04 | 10.59 | 32.09 | 127 | 32.64 | 9.42 | 30.56 | 0.2213 |
| Cystatin-C (mg/L) | 170 | 1.03 | 0.52 | 0.88 | 130 | 0.86 | 0.35 | 0.79 | 0.0003 |
| Cystatin-C >0.96 mg/L | 72 | 42.4% | 33 | 25.4% | 0.0023 | ||||
| MDRD GFR (ml/min/1.73m2) | 170 | 82.76 | 28.66 | 83.60 | 130 | 91.50 | 26.49 | 91.20 | 0.01 |
| MDRD GFR <60 ml/min/1.73m2 | 35 | 20.6% | 14 | 10.8% | 0.0226 | ||||
| CKD-E GFR (ml/min/1.73m2) | 170 | 81.40 | 29.10 | 82.70 | 130 | 91.40 | 26.80 | 93.00 | 0.0059 |
| CKD-E GFR <60 ml/min/1.73m2 | 40 | 23.5% | 17 | 13.1% | 0.0222 | ||||
| Hypertension (%) | 86 | 51.8% | 58 | 45.7% | 0.2977 | ||||
| Diabetes (%) | 22 | 12.9% | 8 | 6.2% | 0.0522 | ||||
| UACR (mg/g) | 170 | 347.22 | 1090.00 | 12.75 | 130 | 84.58 | 198.14 | 7.80 | 0.0339 |
| UACR >30 mg/g (%) | 70 | 41.2% | 38 | 29.2% | 0.0327 | ||||
| UACR >300 mg/g (%) | 28 | 16.5% | 13 | 10.0% | 0.1059 | ||||
| Kidney disease1 (%) | 83 | 48.8% | 43 | 33.1% | 0.0062 | ||||
| Viral load JCV3 | 55 | 5.26 | 1.49 | 5.30 | 35 | 4.94 | 1.56 | 5.09 | 0.2978 |
| Viral load BKV3 | 15 | 4.00 | 0.94 | 3.99 | 14 | 4.04 | 0.90 | 4.07 | 0.532 |
1
Kidney disease is defined as MDRD GFR <60 ml/min/1.73m2 and/or urine albumin:creatinine ratio >30 mg/g.
2
Age difference between participants and the ESRD proband in their family.
3
Viral load (Log10 copies/mL) in subjects with active viral replication.
4
P-values obtained from chi-square tests and Wilcoxon two-sample tests, as appropriate (unadjusted for relatedness). Familial-adjusted pvalues are in Table 2, second column (unadjusted).
BMI body mass index; MDRD Modification of Diet in Renal Disease; GFR glomerular filtration rate; CKD-E CKD EPI; UACR urine albumin:creatinine ratio; JCV JC polyoma virus; BKV BK polyoma virus