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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Hepatology. 2013 Nov 20;59(1):10.1002/hep.26618. doi: 10.1002/hep.26618

Figure 3. JNK-dependence of HCV-induced effects on FOXO3.

Figure 3

A. Western bot analysis of phosphorylated forms of JNK (pJNKT183/Y185) and total JNK in infected and uninfected Huh7.5 cells. B. FHRE-luciferase reporter assays in control and HCV-infected Huh7.5 cells in the presence or absence of JNK inhibitor (SP600125). C. cIEF analysis of FOXO3 species present in nuclear extracts from Huh7.5 cells treated as above. Extracts were probed with either C-terminus (left panel) or aa 280–295 (right panel) FOXO3 primary antibodies. Baseline levels of each trace were shifted as for Fig. 1.