Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Kidney Int. 2013 May 29;84(6):1154–1165. doi: 10.1038/ki.2013.201

Figure 4. Zebrafish Myo1c knockdown induces a renal phenotype.

Figure 4

(A) The histological analysis of 72hpf Myo1c_Chr5_MO and Myo1c_Chr15_MO knockdown embryo sections using Hematoxylin and Eosin (H&E) showed, little alterations of glomerulus but prominent dilation of the pronephric tubules. (B) Ultra-structural analysis of the 96hpf control and morphants glomeruli by TEM showed well developed foot processes in control that appeared as beads on a string, in contrast, knockdown of both the Myo1c homologs showed loss of fine interdigitations and altered foot processes with loss of slit diaphragm (indicated by arrows in the control). Additionally, thickening of GBM was also noted in the morphant embryos (indicated by asterisk).