Table I.
Patient characteristics of atopic and non-atopic groups.
| Overall | Atopic | Non-Atopic | Normal range | p value (significance) | |
|---|---|---|---|---|---|
| Number | 18 | 10 | 8 | ||
| Age (years) | 8 (2-31) | 13 (6-31) | 6 (2-13) | 0.03 (*) | |
| Age at diagnosis of ADA-SCID (months) | 5 (0-60) | 6 (2-60) | 2 (0-18) | 0.07 (ns) | |
| CD3 (cells/μl) | 305 (23-2455) | 261 (23-2455) | 368 (116-1047) | 714-2266 cells/μl | 0.46 (ns) |
| % CD4+ | 55.5 (6-83) | 56 (10-83) | 52 (6-64) | 27-59 | 0.93 (ns) |
| % CD8+ | 34 (4-86) | 28 (4-86) | 38 (22-86) | 13-33 | 0.51 (ns) |
| % CD4-CD8− | 6.5 (1-29) | 5 (1-21) | 9 (3-29) | 1.3-9.2 | 0.31 (ns) |
| CD4:CD8 ratio | 1.77 (0.07-5.29) | 2.08 (0.12-5.29) | 1.29 (0.07-2.88) | 1.11-5.17 | 0.57 (ns) |
| % HLA-DR+ | 42 (10-81) | 47 (22-81) | 34 (10-67) | 0-19.6 | 0.13 (ns) |
| IgE (IU/ml) | 230 (0-2808) | 879 (42-2808) | 28 (0-612) | 0-90 | 0.0009 (***) |
| Absolute eosinophil count (cells/μl) | 202 (10-1840) | 160 (60-1840) | 265 (10-1030) | 30-470 | 0.56 (ns) |
| Clinical Allergy | |||||
| Allergic rhinitis | 50.0% | 80.0% | 25% | ||
| Asthma | 22.2% | 40.0% | 0.0% | ||
| Atopic dermatitis | 11.1% | 10.0% | 12.5% | ||
| Food allergy | 11.1% | 20.0% | 0.0% | ||
| Urticaria | 11.1% | 20.0% | 0.0% | ||
| Number (%) with ≥1 positive allergen skin prick test | 6 of 9 (66.7%) | 6 of 7 (85.7%) | 0 of 2 (0%) | ||
| Number (%) with ≥1 positive allergen specific IgE | 7 of 13 (53.8%) | 7 of 8 (87.5%) | 0 of 5 (0%) | ||
| Current PEG-ADA use | 12 | 9 | 3 | ||
| PEG-ADA alone (No prior BMT or GT) | 2 | 1 | 1 | ||
| Post BMT, on PEG-ADA | 5 | 3 | 2 | ||
| Post GT, on PEG-ADA | 5 | 5 | 0 | ||
| No current PEG-ADA use | 6 | 1 | 5 | ||
| Post BMT, off PEG-ADA | 1 | 0 | 1 | ||
| Post GT, off PEG-ADA | 5 | 1 | 4 |
Age, lymphocyte subsets, IgE, and eosinophil count represent median (range) values. P values <0.05 are considered significant; ns=non-significant