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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Alcohol. 2013 Oct 11;47(8):10.1016/j.alcohol.2013.09.043. doi: 10.1016/j.alcohol.2013.09.043

Figure 3.

Figure 3

TNFα production in response to LPS challenge A. TNFα levels collected from plasma immediately prior to (pre-LPS) or 2 h following (post-LPS) intraperitoneal injection with LPS (500 μg/kg). TNFα levels were undetectable in all samples prior to LPS injection. LPS robustly induced TNFα levels in wild type (p ≤ 0.01; n = 4) and heterozygous (p < 0.05; n = 4) rats but not in the homozygous rats (n = 6). LPS-induced TNFα levels in homozygous rats were reduced compared to heterozygous (p < 0.05) and wild type (p ≤ 0.01) rats. *p < 0.05; **p ≤ 0.01.