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. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: J Vasc Surg. 2013 Jun 12;59(3):804–813. doi: 10.1016/j.jvs.2013.03.047

Carotid Artery Histology and Morphometry. A. Upper panel shows artery wall architecture (adventitia, media, intima) in unligated (control) carotid arteries of WT and rKO mice, which was normal and similar for both 28 days after contralateral carotid ligation. Bottom panel shows ligated carotid arteries for both groups. WT mice demonstrated more shrinkage of the ligated artery wall and lumen (constrictive remodeling) than rKO mice. B. Morphometry data for the ligated arteries from each group are summarized in bar charts. rKO mice (n=16) demonstrated significantly thicker adventitia, larger artery (EEL area), and larger lumen area but not difference in neointimal hyperplasia. A, adventitia; N, neointima; L, lumen; IEL, internal elastic lamina; EEL, external elastic lamina; **, p≤0.01. All panels, X200 magnification.

Carotid Artery Histology and Morphometry. A. Upper panel shows artery wall architecture (adventitia, media, intima) in unligated (control) carotid arteries of WT and rKO mice, which was normal and similar for both 28 days after contralateral carotid ligation. Bottom panel shows ligated carotid arteries for both groups. WT mice demonstrated more shrinkage of the ligated artery wall and lumen (constrictive remodeling) than rKO mice. B. Morphometry data for the ligated arteries from each group are summarized in bar charts. rKO mice (n=16) demonstrated significantly thicker adventitia, larger artery (EEL area), and larger lumen area but not difference in neointimal hyperplasia. A, adventitia; N, neointima; L, lumen; IEL, internal elastic lamina; EEL, external elastic lamina; **, p≤0.01. All panels, X200 magnification.