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Initial Slopes (10-30 min) of Partial Cumulative AUC versus Time Plots of [3H]Cefadroxil in Wild-Type and PepT1 Knockout Mice after Escalating Oral Doses of Drug
| Dose (nmol/g) | Wild-Type (WT) | PepT1 Knockout (KO) | KO/WT |
|---|---|---|---|
| Initial Slope | |||
| 44.5 | 30.5 ± 2.7 | 1.18 ± 0.13*** | 0.039 |
| 89.1 | 62.9 ± 6.1 | 2.00 ± 0.22*** | 0.032 |
| 178 | 109 ± 11 | 5.79 ± 0.94*** | 0.053 |
| 356 | 267 ± 22 | 12.8 ± 2.8*** | 0.048 |
Data are presented as mean ± SE (n=6-8).
* p < 0.05,
** p < 0.01 and
p < 0.001, as compared to wild-type mice.
