Table III.
Pharmacokinetic Parameters of [3H]Cefadroxil in Wild-Type and PepT1 Knockout Mice after 44.5 nmol/g Intravenous Bolus Doses of Drug.
| Parameter | Wild-Type (WT) | PepT1 Knockout (KO) | KO/WT |
|---|---|---|---|
| AUC0-120 (min•μM) | 3224 ± 312 | 3363 ± 488 | 1.04 |
| CL (mL/min) | 0.288 ± 0.039 | 0.292 ± 0.034 | 1.01 |
| MRT0-inf (min) | 27.0 ± 1.9 | 27.2 ± 1.6 | 1.01 |
| T1/2 (min) | 32.6 ± 1.9 | 27.2 ± 2.5 | 0.83 |
| Vdss (mL) | 10.8 ± 1.2 | 10.0 ± 2.0 | 0.93 |
Data are presented as mean ± SE (n=6-8).
There are no significant differences between genotypes in the pharmacokinetic parameters of cefadroxil after intravenous bolus doses of drug.