Table 2.
Comparison of several neurological, respiratory, and hemodynamic variables and dose of the used drugs between the start and the end (at 8 hours) of the study period.
| Number (%) | Start | 8 hours | P-value | |
|---|---|---|---|---|
| Neurological | ||||
| Propofol (mg/kg/hr) | 35 (71%) | 2.3 ± 0.9 | 2.3 ± 1.0 | 0.99 |
| Midazolam (mg/kg/hr) | 31 (69%) | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.81 |
| Remifentanil (µg/kg/min) | 39 (87%) | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.80 |
| Cisatracurium (mg/kg/hr) | 9 (20%) | 0.1 ± 0.1 | 0.1 ± 0.05 | 0.77 |
| SAS (1–7) | 45 (100%) | 1.9 ± 1.1 | 1.6 ± 1.1 | 0.28 |
| GCS (3–15) | 45 (100%) | 4.5 ± 3.1 | 4.8 ± 3.7 | 0.67 |
| Respiratory system | ||||
| pO2/FIO2 | 45 (100%) | 290 ± 171 | 274 ± 149 | 0.64 |
| Minute ventilation (L/min) | 45 (100%) | 11.3 ± 3.5 | 11.2 ± 4.0 | 0.92 |
| pH | 45 (100%) | 7.3 ± 0.1 | 7.3 ± 0.1 | 0.45 |
| EVLWI (mL/kg) | 45 (100%) | 10.2 ± 3.7 | 10.3 ± 3.4 | 0.89 |
| Hemodynamics | ||||
| Norepinephrine (µg/kg/min) | 35 (78%) | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.90 |
| Dobutamine (µg/kg/min) | 27 (60%) | 4.1 ± 1.8 | 4.5 ± 2.2 | 0.49 |
| MAP (mmHg) | 45 (100%) | 79.6 ± 16.9 | 82.9 ± 21.1 | 0.41 |
| Heart rate (BPM) | 45 (100%) | 90.3 ± 25.4 | 88.0 ± 23.7 | 0.66 |
| CVP (mmHg) | 45 (100%) | 10.5 ± 5.3 | 10.1 ± 3.7 | 0.65 |
| TDCO (L/min) | 45 (100%) | 6.2 ± 2.1 | 6.9 ± 2.2 | 0.14 |
| GEF (%) | 45 (100%) | 22.8 ± 8.2 | 24.2 ± 8.6 | 0.45 |
| GEDVI (mL/BSA) | 45 (100%) | 715 ± 192 | 737 ± 162 | 0.56 |
| SVRI (dyne·s·cm−5/m²) | 45 (100%) | 1868 ± 764 | 1877 ± 793 | 0.56 |
| SVV (%) | 45 (100%) | 15.0 ± 8.8 | 12.3 ± 7.3 | 0.12 |
| PPV (%) | 45 (100%) | 14.6 ± 9.7 | 12.1 ± 7.9 | 0.17 |
| Other | ||||
| IAP (mmHg) | 45 (100%) | 7.9 ± 2.9 | 8.8 ± 3.4 | 0.15 |
| Body Temperature (°C) | 45 (100%) | 35.4 ± 1.7 | 35.5 ± 1.7 | 0.76 |
CVP: central venous pressure.
EVLWI: extravascular lung water index.
GCS: Glasgow coma scale.
GEDVI: global end-diastolic volume index.
GEF: global ejection fraction.
IAP: intra-abdominal pressure.
MAP: mean arterial pressure.
PPV: pulse pressure variation.
SAS: sedation and agitation scale.
SVRI: systemic vascular resistance index.
SVV: stroke volume variation.
TDCO: thermodilution cardiac output.