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. Author manuscript; available in PMC: 2014 Oct 17.
Published in final edited form as: Cell Rep. 2013 Sep 27;5(1):10.1016/j.celrep.2013.08.041. doi: 10.1016/j.celrep.2013.08.041

Figure 5. Both MUS81 and SLX1 interactions with SLX4 are necessary for the formation of SLX4-dependent sister chromatid exchanges.

Figure 5

(A). Quantification of sister chromatid exchanges (SCEs) after SLX4-null and complemented cells were treated with low levels of interstrand crosslinking agents (one hour treatment with 0.1 micrograms of MMC per mL of media) (B). Quantification of SCEs after siRNA-mediated depletion of GEN1 from SLX4-null or WT complemented cells and treatment with low levels of interstrand crosslinking agents. (C). Quantification of SCEs after siRNA mediated depletion of BLM from SLX4-null and complemented cells. SCEs were scored blindly (A and C) and not blindly (B) on 20 metaphases from each cell line. Means and standard deviations are given above the graphs. Significance was determined by one-way ANOVA. p values are indicated for the statistically significant comparisons. See also Figure S4.