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Study design. *Glimepiride was initiated at 1 mg/day, with the recommendation to uptitrate if fasting plasma glucose levels (assessed by home monitoring) were >110 mg/dL, to 2 mg/day at week 4, to 3 mg/day at week 8, and to a maximum of 4 mg/day at week 12. Uptitration can be withheld if it would place the patient at risk of hypoglycemia. Glimepiride dose can be downtitrated at any time to prevent recurrent hypoglycemia.
