Figure 3.

Histopathologic appearances of H&E-stained liver, spleen, kidney, brain, duodenum and jejunum of two humanely euthanized beagles infected experimentally CPV-JS2. A: liver, showing extensive degenerated hepatocytes, hyperemia of hepatic sinusoid; 100×. B: spleen, showing the significantly thickened periarterial lymphatic sheath (t), and the hyperemia in artery of spleen trabecular (h); 100×. C: kidney, showing endothelium and mesenchymal cell proliferation in glomerulus, and renal tubules epithelia degeneration and necrosis; 400×. D: brain, showing neuronophagia (arrow); 400×. E: duodenum, showing necrosis of mucous membrane (arrow) and cell proliferation in lamina propria; 100×. F: jejunum, showing necrotic epithelia; 100×.