Table 2.
Logrank test (Mantel-Cox)
| Lymph node metastasis | Primary site recurrence | Distant metastasis | OSCC death 7 | |
|---|---|---|---|---|
|
Gene expression ratio |
|
|
|
|
| High-ITGA3/CD9 |
0.000 |
0.005 |
0.001 |
0.000 |
| High-ITGB4/JUP |
0.022 |
0.237 |
0.000 |
0.001 |
|
Clinicopathological parameter |
|
|||
| Age1 |
0.449 |
0.321 |
0.207 |
0.365 |
| Sex |
0.417 |
0.858 |
0.149 |
0.584 |
| Size2 |
0.000 |
0.007 |
0.703 |
0.084 |
| T3-43 |
0.000 |
0.000 |
0.390 |
0.092 |
| YK44 |
0.000 |
0.018 |
0.001 |
0.000 |
| Positive margin5 |
------ |
0.000 |
0.427 |
0.000 |
|
Clinical event |
|
|||
| Lymph node metastasis6 |
------ |
0.001 |
0.000 |
0.000 |
| Primary site recurrence |
------ |
------ |
0.840 |
0.000 |
| Distant metastasis | ------ | ------ | ------ | 0.000 |
Numbers in the table show P-values for the parameters. 1Age was categorized into two groups ≥69 and <69 based on the median age. 2Major width of the tumor was categorized into >30 mm and ≤30 mm. 3 T3 to T4 of tumor (T) category according to the International Union Against Cancer (UICC) TNM classification of malignant tumors of the lip and oral cavity. 44c or 4d of the histopathologic classification of oral squamous cell carcinoma according to Yamamoto et al., 1983 (10). 5Histological tumor positive of the surgical margin. 6Determined by pathologic examination of a surgical specimen. 7Death outcome from oral squamous cell carcinoma. Continuous variables of gene expression ratios are categorized according to the cut off points introduced by receiver operating characteristic curves. Median of ITGA3/CD9 and higher 30% group of ITGB4/JUP are used for categorization.