Table 1.

Modified diagnostic criteria for PG[1,18-23]

I. main criteria	Primary sterile pustule or ulcer with livid, undermined wound-border [1,14,15,18-21]
	Exclusion of other relevant differential diagnoses like chronic venous/arterial leg ulcer, pyodermatitis, vasculitis [1,14,15,18-20]
II. additional criteria	Histology of the wound-border: neutrophilic infiltration of the dermis with signs of vasculitis and accumulation of immunglobulins and/or complement factors beside the vessels [14,15,20]
	Existence of relevant, associated concomitant diseases like chronic inflammatory bowel diseases, arthropathies, haematological disorders, neoplasia, endocrine dysfunctions, metabolic syndrome [14,15]
	Response to a systemic immunosuppressive therapy or no response to a conventional ulcer-therapy [15,20]
	Triggering of a PG by pathergy-phenomenon [14,15,20]
	Extremely painful ulcer (VAS > 4 points) [14,15]