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. 2013 Sep 8;14:98. doi: 10.1186/1471-2202-14-98

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Copyright © 2013 Cummins et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes in mitochondrial profile cross-sectional area in secondary degeneration +/− R/NIR-IT. Mean area did not change with either injury or R/NIR-IT in axons (A) or glia (B). At day 1 after PT, mitochondrial profiles with smaller areas became more frequent in axons, and this was no longer observed following R/NIR-IT at this time (C). There were no changes in the distributions of glial mitochondria at day 1 (D). At day 7, there was no change in the distribution of area of axonal mitochondrial profiles (E). R/NIR-IT resulted in an increased cumulative probability of mitochondria with smaller cross-sectional areas compared to PT day 7 in glia, however neither the distributions of injured animals (PT) or R/NIR-IT animals (PT 670 nm) were different from normal (F). *Significantly different at p ≤ 0.05.