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. 2013 Sep 8;14:98. doi: 10.1186/1471-2202-14-98

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Copyright © 2013 Cummins et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Quantification of mitochondrial shape changes in secondary degeneration +/- R/NIR-IT. Mean ratios of diameters did not change with either injury or R/NIR-IT in axons (A) or glia (B). At day 1, there was no change in mitochondrial profile shape in axons (C), but a higher probability of more elliptical profiles (signified by larger ratios) was observed in glia (D). Following R/NIR-IT, the distributions of mitochondrial profile shape in glia were not significantly different from normal. At day 7 following injury, the distribution of mitochondrial profile shape was not different compared to normal in axons (E), but again a higher cumulative probability of more elliptical profiles in glia was observed (F); a change which was no longer detected after R/NIR-IT. *Significantly different at p ≤ 0.05.