Table 3.
Percentage of the association between education and incident coronary heart disease mediated by each risk factor determined from the path analysis model in Figure 1 among participants in the follow-up of the Dutch Monitoring Project on Risk Factors for Chronic Diseases (MORGEN) 1994–2008
| Potential mediating risk factor | Percentage of total association mediated by risk factor (95% CI)a,b |
|---|---|
| All mediators (total indirect effect) | 56.6 (42.6, 70.8) |
| Current smoking | 27.3 (17.7, 37.4) |
| Heavy alcohol usec | 2.3 (−0.6, 5.7) |
| Poor dietd | 1.2 (−4.2, 6.3) |
| Physical inactivitye | 6.3 (2.7, 10.0) |
| Obesity | 10.2 (4.5, 16.1) |
| Hypertension | 5.3 (2.8, 8.0) |
| Diabetes | 0.5 (0.1, 1.0) |
| Hypercholesterolemia | 3.5 (1.6, 5.9) |
a
Calculated as [indirect effect/(total indirect effect + direct effect)]*100
b
Based on regression models adjusted for age, sex, and marital status
c
Heavy alcohol use is defined as consuming > 3 drinks/day for men and > 2 drinks/day for women.
d
Poor diet is defined as having a modified Mediterranean Diet Score 0–2.
e
Physical inactivity is defined as having a sedentary job and not engaging in any recreational activity.