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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Circulation. 2013 Oct 1;128(14):10.1161/CIRCULATIONAHA.113.001596. doi: 10.1161/CIRCULATIONAHA.113.001596

Figure 3. Dct-expressing Cells in the Atrium Co-express Autonomic Receptors and are Near Autonomic Nerve Terminals.

Figure 3

Immunohistochemistry within the adult mouse atrium using an antibody to Dct demonstrates Dct-positive cells with characteristic morphology (A, D, G, J, and M). Sections were co-stained with antibodies to β1-adrenergic receptor (β1R; B), α1-adrenergic receptor (α1R; E), muscarinic receptor subtype 3 (M3R; H), tyrosine hydroxylase (T-OH; K), and choline acetyltransferase (ChAT; N). Merged images of Dct and each respective antibody are shown, demonstrating co-expression of Dct with β1R (C), α1R (F), and M3R (I) receptors (arrowheads). In addition, presumptive sympathetic nerve terminals that express tyrosine hydroxylase (L) and parasympathetic nerve terminals that express choline acetyltransferase (O) were seen in close proximity to Dct-expressing cells (arrows). Scale bars: 20 μm. Reproduced with permission from Levin et al. J Clin Invest. 119, 3420-3436 (2009).

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