Table 2.

Mean cognitive function test scores averaged over time for women grouped by treatment assignment with adjustment for age and visit.

Cognitive Function Test	Treatment Assignment				Mean Standardized Difference HT Minus Placebo:* SD Units [95% CI]	p-value HT vs Placebo	p-value MPA vs No MPA
	CEE+MPA Mean (SE)	CEE+MPA Placebo Mean (SE)	CEE Mean (SE)	CEE Placebo Mean (SE)
Global cognitive function
TICS-m	38.08 (0.20)	38.26 (0.21)	37.67 (0.26)	37.28 (0.27)	0.02 [−0.08, 0.12]	0.66	0.23
Verbal Memory
EBMT immediate	10.20 (0.07)	10.17 (0.07)	9.98 (0.09)	10.01 (0.09)	−0.00 [−0.09, 0.09]	0.97	0.70
EBMT delayed	9.88 (0.08)	9.78 (0.08)	9.57 (0.10)	9.59 (0.10)	0.02 [−0.07, 0.12]	0.67	0.49
Sum	20.08 (0.13)	19.95 (0.14)	19.55 (0.17)	19.61 (0.18)	0.01 [−0.08, 0.11]	0.82	0.56
Attention
OTMT-A	8.95 (0.13)	8.57 (0.14)	8.97 (0.16)	8.93 (0.17)	−0.06 [−0.15, 0.03]	0.16	0.26
Executive function
OTMT-B	43.26 (2.19)	42.14 (2.32)	46.76 (2.81)	50.02 (2.91)	−0.00 [−0.10, 0.10]	0.95	0.35
Verbal fluency
VF-A	21.04 (0.25)	20.65 (0.27)	18.90 (0.33)	19.91 (0.34)	−0.05 [−0.15, 0.05]	0.29	0.02
Working memory
Digits forward	8.33 (0.11)	8.60 (0.12)	8.64 (0.14)	8.48 (0.14)	−0.02 [−0.12, 0.08]	0.66	0.09
Digits backward	7.10 (0.11)	7.09 (0.12)	7.26 (0.14)	7.11 (0.15)	0.03 [−0.07, 0.13]	0.55	0.62
Sum	15.42 (0.20)	15.69 (0.22)	15.90 (0.26)	15.59 (0.27)	0.00 [−0.10, 0.11]	0.93	0.23
Composite	0.03 (0.04)	0.04 (0.05)	−0.09 (0.06)	−0.08 (0.06)	−0.01 [−0.11, 0.09]	0.78	0.94

^*Ordered so that positive score indicates better cognitive function in HT; Logarithm transformations used for executive function

¹Fitted mean (95% confidence interval) treatment effects for verbal fluency: CEE+MPA 0.07 [−0.06,0.19]; CEE −0.17 [−0.33,−0.02]