Figure 4. The significant comorbidity relationships detected among all pairs of Mendelian diseases.

The upper diagonal of the matrix displays the log₁₀-transformed odds ratios for the significant associations, with gray-scale intensity indicating the effect size of the association. The lower diagonal displays the community structure determined using a network-clustering algorithm (Blondel et al., 2008), with each community corresponding to a unique color and associations between diseases within the same community colored accordingly. The numerical values underlying each association are provided in Table S5. The statistical procedure for generating these values is depicted in Figure S4. An unfiltered version of the matrix is displayed in Figure S5.