Table 1.

dMRI derived parameters - mean (standard deviation) – from ROIs from normal controls (n = 36) and patients with MTLE (n = 25).

Regions	Controls (n = 36)	MTLE (n = 25)	t-statistic	Cohen’s d
MD (μm2/ms)
Early-myelinating
PLIC	0.80 (0.02)	0.82 (0.07)	1.37	0.41
CP	1.04 (0.05)	1.11 (0.12)	2.75	0.81
Late-myelinating
SLF	0.84 (0.03)	0.87 (0.05)	2.06	0.75
ILF	1.05 (0.07)	1.11 (0.14)	1.99	0.74
D∥ (μm2/ms)
Early-myelinating
PLIC	1.34 (0.04)	1.32 (0.09)	−1.06	−0.20
CP	1.69 (0.06)	1.73 (0.13)	1.33	0.38
Late-myelinating
SLF	1.22 (0.03)	1.23 (0.06)	0.04	0.13
ILF	1.55 (0.09)	1.58 (0.16)	0.74	0.37
D⊥(μm2/ms)
Early-myelinating
PLIC	0.52 (0.02)	0.56 (0.06)	2.96	0.97
CP	0.71 (0.05)	0.80 (0.12)	3.41	0.99
Late-myelinating
SLF	0.65 (0.03)	0.69 (0.05)	2.92	0.99
ILF	0.80 (0.06)	0.88 (0.14)	2.68	0.93
FA
Early-myelinating
PLIC	0.54 (0.02)	0.51 (0.03) **	−4.99	−1.42
CP	0.52 (0.03)	0.48 (0.04) **	−4.50	−1.26
Late-myelinating
SLF	0.40 (0.02)	0.38 (0.03) *	−4.01	−1.20
ILF	0.42 (0.02)	0.38 (0.03) **	−5.07	−1.46
MK
Early-myelinating
PLIC	1.14 (0.07)	1.07 (0.12)	−2.76	−0.79
CP	1.11 (0.06)	1.05 (0.08)	−3.13	−0.88
Late-myelinating
SLF	1.15 (0.04)	1.07 (0.07) **	−5.14	−1.47
ILF	0.93 (0.04)	0.85 (0.06) ***	−5.32	−1.49
K∥
Early-myelinating
PLIC	0.72 (0.03)	0.73 (0.04)	0.73	0.20
CP	0.69 (0.03)	0.70 (0.04)	1.32	0.37
Late-myelinating
SLF	0.93 (0.03)	0.90 (0.03)	−3.45	−0.92
ILF	0.71 (0.02)	0.69 (0.04)	−1.90	−0.54
K⊥
Early-myelinating
PLIC	1.58 (0.14)	1.42 (0.24)	−3.07	−0.87
CP	1.58 (0.12)	1.44 (0.16) *	−3.91	−1.07
Late-myelinating
SLF	1.55 (0.09)	1.36 (0.13) ****	−6.31	−1.76
ILF	1.23 (0.08)	1.07 (0.11) ****	−6.58	−1.81

^*p < 0.0018 (Bonferroni corrected significance level)

^**p < 10⁻⁴

^***p < 10⁻⁵

^****p < 10⁻⁶ with the independent sample t-test (two-tailed, unequal variances assumed).