Table 5.

GWAS genes in the top 50 high-impact interactions

	Publication information			Information about genes involved in the PPI
Rank	PMID	Cite count	Pub year	Symbol 1	Symbol 2	Name 1	Name 2	GWAS diseases/traits of 1	GWAS diseases/traits of 2
1	12802337	160	2003	ADIPOQ	ADIPOR2	adiponectin, C1Q and collagen domain containing	adiponectin receptor 2	adiponectin levels
2	8392057	8	1993	NMB	NMBR	neuromedin B	neuromedin B receptor		Retinal vascular caliber
3	16600873	37	2006	NUP93	TMEM48	nucleoporin 93 kDa	transmembrane protein 48	HDL cholesterol
4	12364586	72	2002	DAO	DAOA	D-amino-acid oxidase	D-amino acid oxidase activator		Bipolar disorder and schizophrenia
8	8702721	21	1996	SRC	YWHAG	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide		Multiple sclerosis
12	2996780	64	1985	PRKCA	SRC	protein kinase C, alpha	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Ventricular conduction,Height
14	10766163	6	2000	ESR1	TP53	estrogen receptor 1	tumor protein p53	Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
15	15173068	8	2004	ESR1	GRB2	estrogen receptor 1	growth factor receptor-bound protein 2	Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
16	9568714	278	1998	GATA4	NFATC4	GATA binding protein 4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	Retinal vascular caliber	Height
17	10433554	4	1999	PRKCA	YWHAG	protein kinase C, alpha	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Ventricular conduction,Height	Multiple sclerosis
18	8266076	105	1993	IL2RG	IL4R	interleukin 2 receptor, gamma	interleukin 4 receptor		IgE levels
22	12732139	46	2003	SMAD3	TP53	SMAD family member 3	tumor protein p53	Coronary heart disease,Asthma,Crohn's disease
23	1454855	45	1992	PRKCA	TP53	protein kinase C, alpha	tumor protein p53	Ventricular conduction,Height
24	8266077	115	1993	IL2RG	IL7R	interleukin 2 receptor, gamma	interleukin 7 receptor		Type 1 diabetes,Ulcerative colitis,Multiple sclerosis,Primary biliary cirrhosis
28	15324660	72	2004	TP53	YWHAG	tumor protein p53	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide		Multiple sclerosis
31	15140878	17	2004	ESR1	SRC	estrogen receptor 1	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
34	12878187	1	2003	EGFR	PRKCA	epidermal growth factor receptor	protein kinase C, alpha	Glioma	Ventricular conduction,Height
36	16192271	88	2005	ABCA1	DLG3	ATP-binding cassette, sub-family A (ABC1), member 1	discs, large homolog 3 (Drosophila)	MRI atrophy measures,HDL cholesterol,Lipid metabolism phenotypes,Cholesterol,total,Coronary heart disease
38	17057718	66	2006	GATA3	SATB1	GATA binding protein 3	SATB homeobox 1	Hodgkin's lymphoma	Platelet counts
39	15466214	27	2004	AR	SRC	androgen receptor	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Prostate cancer,Male-pattern baldness,LDL cholesterol
44	8994038	82	1997	GRB2	MAPK1	growth factor receptor-bound protein 2	mitogen-activated protein kinase 1		Multiple sclerosis
46	11782371	15	2002	EP300	ESR1	E1A binding protein p300	estrogen receptor 1		Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
47	12200137	1	2002	IL2RG	SHB	interleukin 2 receptor, gamma	Src homology 2 domain containing adaptor protein B		Brain structure
50	7477400	72	1995	HLA-DRB3	POMC	major histocompatibility complex, class II, DR beta 3	proopiomelanocortin		Type 1 diabetes,Height,Body mass index

Of the top 50 high impact interactions, those in which one or both genes are found to be associated with a disease or trait by genome-wide association studies (GWAS) are shown. GWAS associated genes are shown in bold.