Table 6.
Effects of NAC on proinflammatory mediators and growth modulator in the plasma and colonic mucosa
| Item | Control | AA | NAC |
|---|---|---|---|
| Plasma |
|
|
|
| TNF-α, ng/mL |
0.61 ± 0.17a |
0.84 ± 0.11b |
0.49 ± 0.14a |
| IL-6, pg/mL |
106.4 ± 23.6 |
115.2 ± 34.2 |
113.6 ± 18.3 |
| PGE2, pg/mL |
57.9 ± 11.5 |
55.1 ± 13.1 |
51.9 ± 11.8 |
| EGF, ng/mL |
0.65 ± 0.08ab |
0.60 ± 0.07a |
0.76 ± 0.10b |
| Colonic mucosa |
|
|
|
| IL-6, pg/mL |
134.3 ± 12.7 |
133.6 ± 17.2 |
130.8 ± 11.3 |
| PGE2, pg/mL |
74.5 ± 3.9a |
96.0 ± 14.5b |
90.5 ± 15.0b |
| TGF-α, pg/mL | 3.50 ± 0.83a | 4.28 ± 0.33b | 2.56 ± 0.54c |
Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a, b, c Values within a row with different letters differ (P < 0.05). TNF-α tumor necrosis factor-alpha, IL-6 interleukin 6, PGE2 prostaglandin E2, EGF epidermal growth factor, TGF-α transforming growth factor-α.