Table 4.
Risk of adverse pregnancy outcomes with 95% confidence intervals according to hyperemesis gravidarum (N = 71,468)
| n (%) | Prevalence (%) (95% CI) | Crude odds ratio (95% CI) | Adjusted odds ratio (95% CI)* | Adjusted odds ratio (95% CI)*** | Adjusted odds ratio (95% CI)**** | |
|---|---|---|---|---|---|---|
|
Gestational age < 37 weeks |
3157 (4.4) |
|
|
|
|
|
| No hyperemesis (HG) |
|
4.4 (4.3- 4.6) |
1 Reference |
1 Reference |
1 Reference |
1 Reference |
| HG |
|
5.3 (5.1- 5.4) |
1.21 (0.89-1.65) |
1.18 (0.86-1.60) |
1.15 (0.84-1.57) |
1.02 (0.75-1.40) |
|
Birthweight < 2500 grams |
1791 (2.5) |
|
|
|
|
|
| No HG |
|
2.5 (2.4- 2.6) |
1 Reference |
1 Reference |
1 Reference |
1 Reference |
| HG |
|
2.5 (2.3- 2.6) |
0.98 (0.63-1.53) |
0.80 (0.47-1.36)** |
0.80 (0.47-1.35)** |
0.72 (0.42-1.24)** |
|
Small for gestational age |
6793 (9.5) |
|
|
|
|
|
| No HG |
|
9.5 (9.3- 9.7) |
1 Reference |
1 Reference |
1 Reference |
1 Reference |
| HG |
|
9.6 (9.4- 9.8) |
1.01 (0.80-1.28) |
1.10 (0.87-1.40) |
1.11 (0.87-1.40) |
1.01 (0.80-1.29) |
|
Apgar score after 1 minute < 7 |
3553 (5.0) |
|
|
|
|
|
| No HG |
|
5.0 (4.8-5.2) |
1 Reference |
1 Reference |
1 Reference |
1 Reference |
| HG |
|
3.2 (3.1-3.3) |
0.63 (0.42-0.93) |
0.62 (0.42-0.93)** |
0.62 (0.42-0.93)** |
0.64 (0.43-0.95)** |
|
Apgar score after 5 minutes < 7 |
848 (1.2) |
|
|
|
|
|
| No HG |
|
1.2 (1.1-1.3) |
1 Reference |
1 Reference |
1 Reference |
1 Reference |
| HG |
|
1.2 (1.1- 1.3) |
1.04 (0.55-1.94) |
1.07 (0.56-2.02)** |
1.04 (0.55-1.97)** |
1.11 (0.58-2.12)** |
|
Perinatal death |
167 (0.2) |
|
|
|
|
|
| No HG |
|
0.2 (0.2- 0.3) |
--- |
--- |
--- |
--- |
| HG | 0.0 (−−) |
*Adjusted for maternal age, parity, BMI, education and smoking habits.
**Additional adjustment for gestational age and induction.
***Additional adjustment for asthma, diabetes 1, thyroid disease, depression, anxiety, other psychological problems, anorexia, anemia and vitamin B12 deficiency.
****Adjustment for maternal weight gain during pregnancy.