Table 3.
Comparison of proportions of lymphocyte subpopulations in CMV-seropositive HC and HT
|
Lymphocyte subpopulation |
Healthy controls (HC) |
Hashimoto’s thyroiditis (HT) |
||
|---|---|---|---|---|
| CMV negative (n = 33) | CMV positive (n = 21) | CMV negative (n = 12) | CMV positive (n = 5) | |
|
CD28- (% of CD4+) |
1.0 ± 0.8 (0.8; 0.1-3.0) |
1.9 ± 1.6 (1.9; 0.2-8.4)## |
1.0 ± 0.7 (0.9; 0.3-2.7) |
1.4 ± 1.4 (1.4; 0.1-2.6) |
|
CD28- (% of CD8+) |
9.0 ± 9.4 (5.3; 0.5-32.2) |
7.8 ± 14.1 (2.2; 0.2-61.7) |
14.5 ± 6.1 (13.3; 4.8-26.4)*** |
32.6 ± 17.7 (31.4; 12.3-52.3)** # |
|
CD45RO + (% of CD4+) |
32.5 ± 12.1 (31.5; 4.7-59.4) |
30.7 ± 16.9 (38.4; 1.4-41.9) |
44.2 ± 14.1 (43.6; 23.2-74.7)*** |
50.9 ± 9.2 (47.5; 43.4-66.0)** |
|
CD45RO + (% of CD8+) |
18.7 ± 10.4 (15.7; 0.5-48.3) |
14.3 ± 8.6 (15.7; 0.07-21.6) |
28.5 ± 15.3 (25.6; 11.9-57.8)*** |
30.5 ± 6.6 (27.7; 24.8-40.1)* |
|
CD45RA + CD62L + (% of CD4+) |
61.8 ± 17.6 (65.8; 9.9-88.2) |
62.3 ± 12.6 (62.4; 27.5-80.8) |
54.8 ± 20.2 (53.3; 10.6-85.3) |
53.6 ± 15.5 (60.9; 27.3-66.0) |
|
CD45RA + CD62L + (% of CD8+) |
64.2 ± 15.0 (68.5; 16.7-83.6) |
61.9 ± 15.5 (61.8; 32.2-93.3) |
55.1 ± 14.69 (60.1; 26.5-72.5) |
43.9 ± 13.9 (39.2; 31.4-61.8) |
| CD25 + CD62L + (% of CD4+) | 22.4 ± 11.8 (20.5; 4.5-75.5) | 23.7 ± 14.5 (19.7; 10.8-78.1) | 25.8 ± 7.5 (24.3; 14.2-39.4) | 18.4 ± 2.8 (19.4; 14.7-21.1) # |
Values are given in mean ± standard deviation (median; range). Numbers (n) of investigated samples from HC and HT are given in brackets. For technical reasons, lymphocyte populations were not investigated in all HC and HT.
Difference between HT and HC in the CMV-positive or CMV-negative groups: *** p < 0.01, ** p < 0.02, * p < 0.05.
Difference between CMV-positive and CMV-negative individuals in the HC or HT groups: ## p < 0.02, # p < 0.05.