FIG. 14.

Laminar flow promotes EC migration compared with disturbed flow and static control. The wounded EC monolayers are kept under static conditions or are subjected to laminar or disturbed flow in a stepflow channel. The direction of laminar flow is from left to right. The left-hand side of the zone is denoted as “upstream” side, and the right-hand side is “downstream.” A: phasecontrast images of the EC migration over the 21-h period of time. White vertical lines indicate the locations of wound edges at the beginning of the experiment. B: the net migration distance as a function of time for the cells in the first row at wound edges (both upstream and downstream sides). [From Hsu et al. (259).]