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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Physiol Rev. 2011 Jan;91(1):10.1152/physrev.00047.2009. doi: 10.1152/physrev.00047.2009

FIG. 15.

FIG. 15

VE-cadherin and β-catenin staining in ECs exposed to pulsatile and reciprocating flows. Confluent monolayers of bovine aortic ECs are kept as controls (A, B) or subjected to different flow patterns in a flow chamber. VE-cadherin staining is observed by confocal microscopy. Stainings for VE-cadherin and β-catenin at intercellular junctions are discontinuous after exposing to pulsatile (C, D) or reciprocating (E, F) flow for 6 h. The distribution of these junction proteins becomes continuous around the entire periphery of the cells after 24, 48, or 72 h of exposure to pulsatile flow (G, H, K, L, O, P), but not reciprocating flow (I, J, M, N, Q, R). [From Miao et al. (379).]