Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jun 12;1842(3):463–472. doi: 10.1016/j.bbadis.2013.06.003

Figure 2. Different consequences of HIF expression in tumors and adipose tissue.

Figure 2

A. Rapid cell proliferation during tumor growth elicits hypoxia, which activates HIF1 signaling, VEGF production and angiogenesis. Increased vascularization allows the tumor to grow.

B. HIF1 expression in adipose tissue does not elicit VEGF production, but rather to a pro-fibrotic program, which is followed by inflammation, macrophage infiltration and cell death.