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Selected DH structures and typical catalytic mechanism. (A) Double hot-dog structure in DEBS DH4. The catalytic histidine and aspartate (shown as sticks) are provided from two different monomers. PDB code:3EL6. (B) A typical catalytic mechanism of DH domain. (C) An extended DH dimer conformation exemplified by DEBS DH4. PDB code:3EL6. (D) “V” shaped DH dimer in mFAS. PDB code: 2VZ9. 215×127mm (300 × 300 DPI).
