Figure 8.

Major axonal trajectories from the somatosensory and motor cortex are preserved in the Pax6cKO brain. DiI placement into the SS and M cortex labeled axon bundles that comprised the corticothalamic, thalamocortical, corticopontine, corticotectal, and corticospinal axons. These could be followed extending toward the cerebral peduncle (green arrow) branching off at the ventroposterior or ventroanterior nucleus of the thalamus (THAL; white arrowheads), SC (green arrowheads), and mesencephalon (MES; white arrows). Note that the branch from M or SS cortex toward the SC appears much more prominent in the Pax6cKO brain (green arrowheads in B, B′, D, D′) than in control.